Skin Science

From our inception, Nikko Chemicals has been dedicated to the development of unique skin care ingredients which deliver visible results.
We continue to work towards the development of ingredients with novel mechanisms and proven efficacy. We are the link between the research and the application of new active molecules which increasingly challenge the status quo.
Our efficacy standards are at the forefront of sophisticated skin care, with many of our ingredients with the "golden set" of testing: cell cultures (in vitro), cultured skin models (ex vivo) and actual human skin (in vivo).

Main Areas of Skin Science Research

Pigmentation reduction (skin lightening)
Traditionally the most important category of skin science research in Asia, pigmentation reduction targets spots as the first signs of skin aging. Recent research, furthermore, has shown that pigmentation-reducing skin care is essential not just for Asian skin, but for all skin types. Dark circles under the eyes, an ubiquitous example, have also been proven to be related to melanin synthesis.
We offer a rich and rigorously-tested lineup of active ingredients to reduce skin pigmentation through various mechanisms including tyrosinase activity suppression, melanin synthesis inhibition, corneocyte transparency improvement, and inflammatory cytokines down-regulation.

Anti-aging skin care treats the universal concern with healthy senescence. Our ingredients improve wrinkles, make the skin more elastic, and provide a healthier glow and younger look. Our focus in this category is on vitamin derivatives and our lineup of active ingredients include several proprietary derivatives of vitamins A and C both for the synthesis of collagen and elastin as well as for the improvement of the quality and structural integrity of collagen. Other anti-aging mechanisms of action include: collagenase inhibition, cell viability improvement, and protection of skin cell DNA from UV light and oxidative stress.
Our latest research in anti-aging skin care includes: the distinct and combined treatment of fine lines and deep wrinkles, and the blocking of epidermal-dermal inflammatory cross-talk.
Skin moisturization
The oldest topic of skin care research, the protection and replenishing of skin moisture has long been the most readily recognized concept among consumers. Our ingredients help to enhance the hydrolipidic barrier, hydrate the skin, reduce TEWL (TransEpidermal Water Loss), and establish proper moisture balance.
Nikko Chemicals has probed the surface of this familiar topic with our "Eight Approaches" (link?) to new skin moisture. Our strategies aid in the design of a sophisticated and effective moisturizing product with additional hydro-benefits, including skin lifting and skin elasticity improvement.

Anti-inflammation and anti-irritation
We have a wide range of anti-inflammatory and irritation-reducing active ingredients, many of botanical origin. Lecinol S-10 is a lecithin-type emulsifier with unique anti-irritation properties: the reduction of the irritation potential of surfactants, and the suppression of the skin’s stinging reaction to various irritating substances (tested in vivo).
Many of our actives for the inflammatory cytokine inhibition have been, furthermore, tested for additional effects such as anti-pigmentation and wrinkle reduction.
Anti-oxidation protection is an essential component of any modern skin care. Our wide range of anti-oxidants includes proprietary vitamin derivatives as well as other molecules with a variety of properties: radical oxygen scavenging, glutathione and metallothionein synthesis promotion (stimulation of natural anti-oxidation protection), and protection of mitochondria from oxidative damage. We have recently confirmed that many strong anti-oxidant molecules work in synergy with vitamin C derivatives for a potentiated, even stronger anti-pigmentation effect.

Skin DNA protection and repair
Sunscreen products with SPF (Sun Protection Factor) protect the skin from solar radiation, but do not prevent damage to the skin on the immune level, including damage to DNA and mitochondria. Almost half of this damaging exposure occurs when we are unprepared; for example, when SPF suncare is not available or not applied. Furthermore, over time, our natural capacity to repair UV-damaged DNA declines. We have thus developed and tested a complete series of active molecules which not only protect DNA from immediate UV-induced damage but also stimulate the DNA repair processes naturally in the skin.


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